What was the survival rate for Black Death?
Mortality depends on the type of plague: Bubonic plague is fatal in about 50-70% of untreated cases, but perhaps 10-15% when treated. Septicaemic plague is almost 100% fatal, and perhaps 40% with treatment.
In the study, Barreiro and his colleagues found that Black Death survivors in London and Denmark had an edge in their genes – mutations that helped protect against the plague pathogen, Yersinia pestis. Survivors passed those mutations onto their descendants, and many Europeans still carry those mutations today.
How did it end? The most popular theory of how the plague ended is through the implementation of quarantines. The uninfected would typically remain in their homes and only leave when it was necessary, while those who could afford to do so would leave the more densely populated areas and live in greater isolation.
The disease spread through air, rats, and fleas, and decimated Europe for several centuries. The pandemic eased with better sanitation, hygiene, and medical advancements but never completely disappeared.
Plague can be successfully treated with antibiotics. Once a patient is diagnosed with suspected plague they should be hospitalized and, in the case of pneumonic plague, medically isolated.
The plague caused painful and frightening symptoms, including fever, vomiting, coughing up blood, black pustules on the skin, and swollen lymph nodes. Death usually came within 3 days.
The bottom line
New cases of the bubonic plague found in China are making headlines. But health experts say there's no chance a plague epidemic will strike again, as the plague is easily prevented and cured with antibiotics.
Does the bubonic plague still exist? There have been other episodes of bubonic plague in world history apart from the Black Death years (1346-1353). Bubonic plague still occurs throughout the world and in the U.S., with cases in Africa, Asia, South America and the western areas of North America.
Antiserum. The first application of antiserum to the treatment of patients is credited to Yersin [5], who used serum developed with the assistance of his Parisian colleagues Calmette, Roux, and Borrel.
Black Death, pandemic that ravaged Europe between 1347 and 1351, taking a proportionately greater toll of life than any other known epidemic or war up to that time.
What were the positive effects of the Black Death?
At the same time, the plague brought benefits as well: modern labor movements, improvements in medicine and a new approach to life. Indeed, much of the Italian Renaissance—even Shakespeare's drama to some extent—is an aftershock of the Black Death.
Today, scientists understand that the Black Death, now known as the plague, is spread by a bacillus called Yersinia pestis.

Today, modern antibiotics are effective in treating plague. Without prompt treatment, the disease can cause serious illness or death. Presently, human plague infections continue to occur in rural areas in the western United States, but significantly more cases occur in parts of Africa and Asia.
Bubonic plague is caused by the bacterium Yersinia pestis spread by fleas, but during the Black Death it probably also took a secondary form, spread by person-to-person contact via aerosols causing septicaemic or pneumonic plagues. The Black Death was the beginning of the second plague pandemic.
Plague vaccines ** have been used since the late 19th century, but their effectiveness has never been measured precisely. Field experience indicates that vaccination with plague vaccine reduces the incidence and severity of disease resulting from the bite of infected fleas.
Plague in the United States
The last urban plague epidemic in the United States occurred in Los Angeles from 1924 through 1925. Plague then spread from urban rats to rural rodent species, and became entrenched in many areas of the western United States.
Bubonic plague, the disease's most common form, refers to telltale buboes—painfully swollen lymph nodes—that appear around the groin, armpit, or neck. The skin sores become black, leading to its nickname during pandemics as “Black Death.” Initial symptoms of this early stage include vomiting, nausea, and fever.
It eventually became evident that those few who remained loyal to cats were not falling ill to the plague—because the cats were exterminating the rats that carried the illness! As communities welcomed the propagation of cats again, the rat population declined and the plague lost its vigor.
Italy had been hit the hardest by the plague because of the dense population of merchants and active lifestyle within the city states. For example, the city state of Florence was reduced by 1/3 in population within the first six months of infection.
Patients develop fever, chills, extreme weakness, abdominal pain, shock, and possibly bleeding into the skin and other organs. Skin and other tissues may turn black and die, especially on fingers, toes, and the nose.
How did doctors react to the Black Death?
Even though the Plague killed many, it had beneficial effects on medicine, especially in Europe. Doctors began to question Galenic medicine, they relied more on observation, and they paid more attention to anatomy. There were also improvements in medical ethics, public health, and hospitals.
The beaked masks were filled with theriac, a mixture of more than 55 herbs and other compounds including ingredients such as cinnamon, myrrh, and honey. The shape of the beak was supposedly designed to give the air enough time to be cleansed by the herbs before it reached the nose.
The original carrier for the plague-infected fleas thought to be responsible for the Black Death was the black rat. The bacterium responsible for the Black Death, Yersinia pestis, was commonly endemic in only a few rodent species and is usually transmitted zoonotically by the rat flea.
The plague is caused by a bacteria called Yersinia pestis, which is transmitted by fleas. Infected fleas spread the infection to animals, commonly mice, squirrels, prairie dogs and even cats and dogs. Humans get the plague through direct contact with infected animals or fleas.
Many doctors still got sick by breathing through the nostril holes in their masks. However, some forms of plague only spread through bites from fleas and rodents. The doctor's uniform did help protect them from this hazard. However, it was largely the coat, gloves, boots, and hat that did so—not the bird mask.
The example of the Black Death can be inspiring for dealing with challenges caused by the outbreak of epidemics in our contemporary world. Unlike in the 14th century, today we can identify new viruses, sequence their genome, and develop reliable tests for diseases in just a few weeks.
The consequences of this violent catastrophe were many. A cessation of wars and a sudden slump in trade immediately followed but were only of short duration. A more lasting and serious consequence was the drastic reduction of the amount of land under cultivation, due to the deaths of so many labourers.
Most evidence points to the Black Death being the main bubonic strain of plague, spread far and wide by flea-ridden rats on boats and fleas on the bodies and clothes of travellers.
You can also get it from close contact with infected animals or from bacteria moving to your lungs from another part of your body (secondary infection). Pneumonic plague causes severe pneumonia and respiratory failure. If not treated, most people with pneumonic plague die within days.
"Although the lethality of the plague is very high without treatment it remains likely that specific individuals are protected from, or more susceptible to, severe disease through polymorphism in the determinants of natural immunity," the study said.
Is the plague painful?
Bubonic plague is the most common form and is characterized by painful swollen lymph nodes or 'buboes'. Plague is transmitted between animals and humans by the bite of infected fleas, direct contact with infected tissues, and inhalation of infected respiratory droplets.
Because human plague is rare in most parts of the world, there is no need to vaccinate persons other than those at particularly high risk of exposure. Routine vaccination is not necessary for persons living in areas with enzootic plague such as the western United States.
Patients develop fever, chills, extreme weakness, abdominal pain, shock, and possibly bleeding into the skin and other organs.
Despite the dearth of workers, there was more land, more food, and more money for ordinary people. “You might see this as a benefit to the laboring classes,” she says. DeWitte's more recent studies explore the long-lasting biological impact.
In October 1347, a ship came from the Crimea and Asia and docked in Messina, Sicily. Aboard the ship were not only sailors but rats. The rats brought with them the Black Death, the bubonic plague.